Determinants Of Volume Status In Peritoneal Dialysis: A Longitudinal Study




In peritoneal dialysis (PD), fluid overload is frequent and associated with cardiac dysfunction and mortality. As it is considered a modifiable risk factor, we wished to describe clinical determinants of fluid overload in a longitudinal cohort of PD outpatients.


We consecutively included PD outpatients treated with CAPD or APD attending for their routine clinical visit at a single tertiary hospital. Extracellular water (ECW) to total body water (TBW) ratio was measured by multifrequency bioelectrical impedance (MFBIA). Peritoneal transport characteristics were measured with a standard peritoneal equilibration test. Patients had a second follow‐up visit with the same measurements. Univariable and multivariable mixed linear regression models were conducted with ECW/TBW as the dependent variable.


We confirm a high prevalence of fluid overload in PD patients and show that it is strongly associated with older age, diabetes, hypoalbuminemia and protein energy wasting. In contrast, when PD prescription is tailored to patient's individual characteristics, residual renal function, PD modality and peritoneal characteristics are not decisive in controlling volume status.

This article is protected by copyright. All rights reserved.

Manuscripts can be uploaded online at Editorial Tracking System or as an email attachment to

Thanks and Regards,
Editorial Manager,
Jessica Aron
Clinical Nephrology and Research
Contact: +32-2-808-7017